The mat locus controls expression of the genes that

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Unformatted text preview: velopment in multicellular eukaryotes. The MAT Locus Controls Expression of the Genes That Determine Cell Type A cell with MATa information at the MAT locus has an a mating type. By contrast, a cell carrying MAT information at the MAT locus has an mating type. What at the MAT locus determines these different mating types? Clues to the role of the MAT locus first emerged from mutant analyses. When sterile mutants of cells were isolated, one class of mutants had defects at the MAT locus. har06584_refA_001-020 11/4/06 10:10 AM Page 9 A.2 Cell Differentiation in Yeast: Mechanisms for Determining Cell Type Surprisingly, the MAT mutations fell into two complementation groups, indicating that instead of a single gene at the MAT locus, there are two genes, 1 and 2. Mutations in the 1 and 2 complementation groups produce different molecular effects, which inform us of the roles of the genes. Strains carrying 1 mutations fail to synthesize pheromone, a protein normally made by cells. Strains carrying 2 mutations synthesize a pheromone but degrade it before it can be secreted; normally, only a cells express the ph...
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This note was uploaded on 10/03/2013 for the course BI 206 taught by Professor Celenza during the Spring '08 term at BU.

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