Saccharomyces_A

The dissociated but still membranebound g g dimeric

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Unformatted text preview: causing the conversion of G -GDP to G -GTP and this conversion, in turn, causing the dissociation of the G / G subunits from the heterotrimeric G-protein complex. The dissociated but still membranebound G / G dimeric complex initiates a signal that propagates through the series of proteins in the signal transduction pathway. The pathway ultimately leads to the transcriptional activation of genes whose products are required for G1 cellcycle arrest, cell fusion, and nuclear fusion. Inhibition of a cell growth by α pheromone Diploid cells Wild-type α cells Sterile α mutant unable to make α pheromone Inhibition of α cell growth by a pheromone Sterile α mutant unable to respond to a pheromone Sterile a mutant unable to respond to α pheromone Wild-type a cells Sterile a mutant unable to make a pheromone Figure A.14 Mutants defective in producing or responding to mating signals. Strains can be cross-streaked on plates to test for defects in sending or receiving pheromone messages. Pheromones from a strain of one mating type bind to a strain of the opposite mating type...
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This note was uploaded on 10/03/2013 for the course BI 206 taught by Professor Celenza during the Spring '08 term at BU.

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