This observation demonstrates that in normal sir

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Unformatted text preview: cut in a given cell, HOmediated transposition can occur from MAT to one of the storage loci or in the other direction. This observation demonstrates that in normal SIR strains, the silencing of the storage loci ensures that MAT serves as recipient and the storage loci as donors in the switching process. As a consequence, in wild-type cells, mating type information flows in only one direction—from the storage loci to MAT. The Role of HO in Mating Type Determination and Stability Serves as a Paradigm for Development Pedigrees of cells undergoing HO-mediated mating type switching have revealed a few rules governing mitotic cell lineages during development (Fig. A.12). In a typical pedigree analysis, investigators tease apart the mother and daughter cells in each cell division by delicate micromanipulation under a microscope so that they can examine each one individually. The first generation arises when a spore germinates to produce the spore (S) and the first daughter (D1) (Fig. A.12a). In the...
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This note was uploaded on 10/03/2013 for the course BI 206 taught by Professor Celenza during the Spring '08 term at BU.

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