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Three main themes unify our genetic portrait of yeast.
First, to identify the genes and proteins inﬂuencing development, researchers isolate and study mutants defective for a speciﬁc process. Second,
master regulatory genes in yeast control the expression of other genes, whose activities determine the phenotype of a cell. Third, cascades of proteins called signal
transduction systems (described in Chapter 19 of the main textbook) transmit the
signals responsible for shifting a cell from one phenotype to another. A Yeast colonies, each containing
about 107 cells, grow from single
cells spread on solid media. In examining yeast as a model organism for understanding development,
• An overview of yeast in the laboratory: signiﬁcant details of the yeast life
cycle, current knowledge of the yeast genome, and basic tools for looking
• Cell differentiation: molecular mechanisms for determining cell type.
• Mating: how cell-to-cell communication through pheromones promotes the
conversion of haploid cells...
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- Spring '08
- DNA, MAT locus, Yeast Geneticist