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Unformatted text preview: ination, is about 4400 cM. With an average of
3 kb/cM, genetic distance is roughly proportional to physical distance (Fig. A.4). Exceptions are the rDNA repeats,
in which there is virtually no meiotic recombination, and
the regions surrounding the centromeres, where recombination is modestly suppressed. Because S. cerevisiae has
an unusually active recombination system, the total genetic map of yeast is extraordinarily long compared to
the genetic map of other fungal organisms. Neurospora
crassa, for example, has about the same DNA content as
yeast but a genetic map that is only 15% as long as
yeast’s. HMR ABP1 SUP61 thr4 cry1
MAT pet18 CEN3
leu2 his6 Genetic map HML
cha1 Chromosome III 10 cm HMR ABP1 thr4 SUP61 MAT cry1 pet18 pgk1 CEN3 SUP53
leu2 glk1 his6 HML
cha1 20 kb
Physical map Figure A.4 Comparison of genetic and physical maps. The location of genes on chromosome III as determined by recombination
distances (genetic map) and sequencing DNA (physical map) are shown...
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This note was uploaded on 10/03/2013 for the course BI 206 taught by Professor Celenza during the Spring '08 term at BU.
- Spring '08