With an average of 3 kbcm genetic distance is roughly

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Unformatted text preview: ination, is about 4400 cM. With an average of 3 kb/cM, genetic distance is roughly proportional to physical distance (Fig. A.4). Exceptions are the rDNA repeats, in which there is virtually no meiotic recombination, and the regions surrounding the centromeres, where recombination is modestly suppressed. Because S. cerevisiae has an unusually active recombination system, the total genetic map of yeast is extraordinarily long compared to the genetic map of other fungal organisms. Neurospora crassa, for example, has about the same DNA content as yeast but a genetic map that is only 15% as long as yeast’s. HMR ABP1 SUP61 thr4 cry1 MAT pet18 CEN3 pgk1 SUP53 leu2 his6 Genetic map HML glk1 cha1 Chromosome III 10 cm HMR ABP1 thr4 SUP61 MAT cry1 pet18 pgk1 CEN3 SUP53 leu2 glk1 his6 HML cha1 20 kb Physical map Figure A.4 Comparison of genetic and physical maps. The location of genes on chromosome III as determined by recombination distances (genetic map) and sequencing DNA (physical map) are shown...
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