Saccharomyces_A

Har06584refa001 020 14 11406 1010 am page 14 reference

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Unformatted text preview: and this binding leads to the arrest of cell division. If a cell cannot produce or respond to one of the pheromones, there will be no inhibition where the streaks cross. har06584_refA_001-020 14 11/4/06 10:10 AM Page 14 Reference A Saccharomyces cerevisiae: Genetic Portrait of a Yeast α pheromone (from α- type cell) STE3 α-factor receptor α Outside Plasma membrane αγ β GDPP Inside Genome-Wide Analyses of the Pheromone Response G protein P α α SCG1 GTP P γ STE18 STE4 β P P Signal STE5 MAP kinase cascade STE11 STE7 FUS3 Dig1 Dig1 P Dig2 Dig2 P STE12 STE12 Inactive FAR1 yeast mating response by genetic and molecular analyses are remarkably conserved in all eukaryotes. P Changes in G1cyclin abundance G1 arrest Active P Transcription FUS1 Cell fusion KAR5 Nuclear fusion Mating Figure A.15 Signal transduction cascade in the mating response. Binding of pheromone to a receptor causes the conversion of GDP to GTP, which then activates the MAP kinase cascade, leading to activation of the STE12 transcriptional activator. Activated STE12...
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