Lab+9_endocrine+disruptors_Graham+edits - Lab Report...

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Lab Report – Session 9 Endocrine Disruptors Carly Kruchten-Sheridan Thursday November 2, 2006 Poev Touch Graham Barnett Part 1 1) At least five specific changes in men’s reproductive health are covered in the video. List three of them. - Increase in abnormal sperm compared to the normal amount of abnormal sperm present - Decrease in sperm count /volume - Increase in testicular non-de s cent” (AKA: undescended testies) - Increase in testicular cancer - Ambiguous penis shape 2) If Sertoli cell number decreases, sperm production decreases. Explain the functional connection between the two cell types. Sertoli cells function to allow spermatids to attach for nourishment during the sperm production cycle. Sertoli cells are only produced from conception till puberty, once spermatogenesis has begun sertoli cell growth stops. Sertoli cells then function to nurture the sperm cells through their growth process. If the number of sertoli cells is lessened because of one factor or another, the amount of sperm production will also be reduced. Sertoli cells also regulate when the testies descend. 3) What is DES? Why was it prescribed? What side effects occurred because of its use? Considering who experienced these side effects, what does this say about when and individual is sensitive to the known side effects of DES? DES is a synthetic estrogen also known as Diethylstilbestrol. DES supplements a woman’s natural estrogen and was originally prescribed because it was believed to help prevent miscarriages and premature births. DES is a known teratogen and is also thought to increase the incidence of multiple types of cancer. It was given to pregnant mice for two days: the result was that the offspring’s had both male and female reproductive organs. Normal mice start out with both organs and then develop into either male or female, but this step is blocked by DES. Male mice that had been treated express female proteins even in adulthood
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This lab report was uploaded on 04/07/2008 for the course PHRM 223 taught by Professor Gerald during the Fall '05 term at UConn.

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Lab+9_endocrine+disruptors_Graham+edits - Lab Report...

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