Lab 12 - glutamate thus preventing excitotoxicity in the...

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Carly Kruchten-Sheridan Lab Report – Session 12 Poev Touch Memory Drugs and Alzheimer’s Graham Barnett 1) List the 3 major hallmarks of Alzheimer’s disease. Neurofibrillary Tangles Neuritic Plaques AB oligomers 2) Microscopically, where are plaques and tangles formed in AD? Plaques form outside of the brain cells Tangles build up with in the neurons 3) Even though there is no cure for AD, there are some steps that can be taken to try to lower disease risk or may slow its progression. What are some of the things that a middle-aged person could do that may lower risk? Passive activity (watching tv) Intellectual activity (reading) Physical activity (walking) 4) What are the two classes of approved medications for AD, and how do they work? Namenda is a NMDA receptor antagonist, which blocks the over stimulation from
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Unformatted text preview: glutamate, thus preventing excitotoxicity in the neuron that is thought to cause AD. Abnormal glutamate production and stimulation is thought to produce neuronal dysfunction and cell death. With Namenda, this overstimulation is blocked and symptoms may improve. Aricept is a AChE inhibitor, which blocks the breakdown of acetylcholine. As neurons die from the disease, the amount of Ach within the synapses is reduced. Aricept blocks the metabolism of ACh thus increasing the amount and improving synaptic cell-to-cell communication and symptoms. 5) What are the risk factors for sporadic AD? Name several factors (at least 2). Age Female Apo E4 Mutation...
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