Atrial muscle cells released in response to the

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Unformatted text preview: April 30, 12 Atrial Natriuretic Peptide (ANP) • • Synthesized, stored, and released by specialized atrial muscle cells Released in response to the stretching of the atrial muscle • Triggers of ANP release – High Blood volume – Angiotensin stimulation – Sympathetic stimulation Elevated levels of ANP are found during hypervolemic states (elevated blood volume) and congestive heart failure ANP reduces extracellular fluid volumes Monday, April 30, 12 • Congestive Heart Failure – 2% prevalence rate – 10% in those >65 • Symptoms – Weakening of heart muscle – Reduction in stroke volumes • Heart muscle tries to compensates by stretching to increase stroke volume – Stretching triggers release of ANP • ANP triggers loss of Na+ and water thus lowering blood volume • GFR drops: Not a desirable outcome • One reason why increasing the heart stroke volume is no longer the preferred therapy for congestive heart failure Monday, April 30, 12 Class Compound Mechanism of action Loop diuretics Furosemide (frusemide) Inhibit triporter pump in thick ascending loop of Henle, thus inhibiting Na+ and Cl− reabsorption, which leads to diuresis and potentially hypokalemia Thiazide diuretics Bendrofluazide, Inhibit NaCl reabsorption in the distal tubule. The greater Na+ load in the distal tubule stimulates Na+ exchange with K+ and H+, causing hypokalemia and metabolic alkalosis Metolazone Particularly potent diuretic, especially when combined with a loop diuretic PotassiumAmiloride sparing diuretics Spironolactone Blocks Na+ channels in the distal nephron Aldosterone antagonist Monday, April 30, 12...
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This note was uploaded on 10/10/2013 for the course BIO 1440 taught by Professor Booker during the Spring '13 term at Cornell University (Engineering School).

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