PSIO #9 Lecture REAL

Differentiation osteoblasts differentiation is change

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Unformatted text preview: Divide first so they cells do not run out of cells. Differentiation Osteoblasts Differentiation is change in cell structure and function. Osteoblasts "b" for build • Cells that build bone bone formation • Synthesize organic components of matrix • Initiate calcification – take calcium from blood and deposit it within matrix by exocytosis This calcium hardens, and they become trapped in the matrix they produce, and then differentiate into osteocytes. Immature cells Anything that ends in "cyte" is mature. Anything that end in "blasts" are immature. Both immature and become mature when they can differentiate into osteoclasts. Osteocytes • Mature cells involved in maintenance of bone Osteocyte with its dendritic processes Called this because they look like nervous tissue in the cell body. Osteoporosis, 3rd ed, Marcus, Feldman, Nelson, Rosen. Bone form and function. 2008 Osteoclasts • Break down bone bone resorption • Release proteolytic enzymes and acids to degrade collagen and releas...
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