Unformatted text preview: zyme.
- enzyme has 2 active sites: tether swing the
biotin from site 1 to site 2
-required ATP to activate co2
pyruvate + co2 + ATP -->
*require biotin. 2 active sites and 1 tether biotin tether: swing around active sites, carry CO2 -isozyme: same enzyme but different
structure and function.
--> Mt or cytosolic malate
dehydrogenase inside Mt: lots of CO2, high conc. of
NADH from Kreb's cycle. -inside mitochondria has small
pool size of NAD+, so Mt won't let
NAD+ diffuse out into cytosol
--> reduce oaa down to Malate, so it
can diffuse out to cytosol -inner membrane: need transfer protein to help
compounds to enter...
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