D i s o r d e r t h a t t o o k t h e l i f e o f f o

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Unformatted text preview: e l i f e o f f o l k s i n g e r W o o d y G u t h r i e . H u n t i n g t o n ’s A t t h e m o lec u lar lev el, th e d iffer en c e b etw een L e ( t all p lan t ) d i s e a s e i s c a u s e d b y a d o m i n a n t g e n e w h i c h , m e r c i f u l l y, i s r a r e . an d le ( sh o r t p lan t) is a sin g le am in o ac id su b stitu tio n in th e en z y m e G A 3 - b et a- h y d r o x y lase, a p r o t ein 3 7 4 am in o ac id s l o n g . I n th is p ro tein , th e 2 2 9 th am in o ac id in th e activ e p ro tein (L e) is alan in e; in th e in activ e p ro tein (le) it is th reo n in e. T h e o rd er T h e G e n e f o r Ta ll P e a s C o d e s f o r a n o f am in o acid s in a p ro tein d eter m in es h o w th e p ro tein w ill fo ld E n z y m e R e q u ir e d t o M a k e G ib b e r e llin ( it s t er t iar y st r u c t u r e) ; t h is sin g le a m in o ac id su b st i t u t i o n c au ses T al l p ea p lan t s, o v er 6 feet t all ( L e) , ar e d o m in an t t o sh o r t p lan t s, en o u g h o f a c h an g e i n t h e t er t i ar y st r u c t u r e o f t h e en z y m e t o le ss t h an 1 fo o t t all ( le) . T h e le g en e i s lo c at ed o n c h r o m o so m e 4 . r en d er it in ac t iv e. T h i...
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This note was uploaded on 10/16/2013 for the course BBIO 360 taught by Professor Marcservetnick during the Fall '12 term at University of Washington.

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