Unit 3 Study Guide
Professor Friedrichsen Fall 07
1. Sickle cell anemia:
Inherit it from both carrier parents, with 2 mutated genes (nn)
b) How is it inherited?
You inherit one mutated gene from each carrier parent.
You inherit 2 copies of the mutated beta hemoglobin gene, making only sickle beta
Blood transfusion, bone marrow transplant, gene therapy
e) Explain how drugs targeted at gene expression work to cure sickle cell anemia.
drugs keep the fetal hemoglobin gene switched on, no sickle disease
f) How does the DNA mutation affect the protein
: changes an amino acid
(changing the 3d shape
Cell becomes stiff and sickle-shaped, RBC tissue,
chronic anemia, jaundice, paint episodes, stroke risk, infection
problems, stunt growth, short life expectancy
Why are there more sickle cell anemia carriers in Africa and the Mediterranean than in
? Because malaria is more popular over there and makes it easier to get sickle
cell and die then in America
3. What is malaria?
Parasites that infects red blood cells, Infected by mosquito bite
Chills, fever, headaches, vomiting
What is a point mutation?
Single base change ex: sickle (A
What effects can it have on a protein?
Changes the amino acids, which then changes
the 3D shape
5. What is a reading frame shift mutation?
1 or 2 bases are added or deleted
What effect can it have on a protein?
Makes protein non functional
Mitosis: What is it?
Process of separating the duplicated chromosome
What happens during mitosis?
chromosomes, duplicated chromosomes line up in the middle of the cell,
sister chromatids are separated, each one is pulled to the opposite pole.
Consistency, two identical cells with identical DNA
Where does mitosis occur?
All over the body
2. Know the differences between:
b) duplicated chromosome
c) sister chromatids