Unit 3Study Guide

Unit 3Study Guide - 1 Unit 3 Study Guide Professor...

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Unit 3 Study Guide Professor Friedrichsen Fall 07 1. Sickle cell anemia: a) Cause? Inherit it from both carrier parents, with 2 mutated genes (nn) b) How is it inherited? You inherit one mutated gene from each carrier parent. You inherit 2 copies of the mutated beta hemoglobin gene, making only sickle beta hemoglobin chains c) Symptoms? D) Treatments? Blood transfusion, bone marrow transplant, gene therapy Potential Cures? e) Explain how drugs targeted at gene expression work to cure sickle cell anemia. - drugs keep the fetal hemoglobin gene switched on, no sickle disease f) How does the DNA mutation affect the protein : changes an amino acid (changing the 3d shape ) , cell: Cell becomes stiff and sickle-shaped, RBC tissue, organ and organism: chronic anemia, jaundice, paint episodes, stroke risk, infection problems, stunt growth, short life expectancy 2. Why are there more sickle cell anemia carriers in Africa and the Mediterranean than in the US ? Because malaria is more popular over there and makes it easier to get sickle cell and die then in America 3. What is malaria? Cause? Parasites that infects red blood cells, Infected by mosquito bite Symptoms? Chills, fever, headaches, vomiting 4. What is a point mutation? Single base change ex: sickle (A T) What effects can it have on a protein? Changes the amino acids, which then changes the 3D shape 5. What is a reading frame shift mutation? 1 or 2 bases are added or deleted What effect can it have on a protein? Makes protein non functional 1. Mitosis: What is it? Process of separating the duplicated chromosome 2. What happens during mitosis? Chromosomes condense duplicated chromosomes, duplicated chromosomes line up in the middle of the cell, sister chromatids are separated, each one is pulled to the opposite pole. 3. End result? Consistency, two identical cells with identical DNA Where does mitosis occur? All over the body 2. Know the differences between: a) chromosome b) duplicated chromosome c) sister chromatids 1
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d) chromatin 2. Be able to draw the Cell Cycle, label and explain each of the following phases: a) G 1 : “Gap 1” cell grows b) S : “synthesis” DNA is replicated c) G 2 : “Gap 2” cell growth, prep for division d) M : DNA is divided (sister chromatids separate) e) cytokinesis : cytoplasm is divided 3. Be able to explain the telomere hypothesis of aging. Every time the cell divides, the telomeres shorten, normal body cell can
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This note was uploaded on 04/08/2008 for the course BIO 110 taught by Professor Unknown during the Spring '08 term at Missouri (Mizzou).

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Unit 3Study Guide - 1 Unit 3 Study Guide Professor...

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