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Unformatted text preview: lomeres are repetitive non-coding DNA
at ends of linear chromosomes Telomerase is an enzyme with both RNA
and protein components
Telomerase RNA acts as a template “coding” DNA is a template for RNA / protein.
Our DNA is a mixture of coding DNA sequences
interspersed with regions of non-coding DNA
Telomeres do not encode instructions for making
a specific RNA or protein, so they are “noncoding” The protein
is called TERT 5 9/21/10 Telomere = DNA at ends of chromosomes
Telomerase = enzyme that can synthesize the
5’ ends of lagging strands during replication,
using telomeric DNA as the template. Why did this discovery merit a Nobel Prize?
HUGE discovery for basic science
implications for human medicine
http://nobelprize.org/nobel_prizes/medicine/laureates/2009/press.html Telomeres and Telomerase The initial discoveries
Elizabeth Blackburn and Jack
Szostak discovered the protective
functions of telomeres.
Carol Greider, as a graduate
student in Elizabeth Blackburn’s
lab, isolated telomerase from
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- Fall '13