212_Enger-2011-09-23-stdt

Our dna is a mixture of coding dna sequences

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Unformatted text preview: lomeres are repetitive non-coding DNA at ends of linear chromosomes Telomerase is an enzyme with both RNA and protein components Telomerase RNA acts as a template “coding” DNA is a template for RNA / protein. Our DNA is a mixture of coding DNA sequences interspersed with regions of non-coding DNA Telomeres do not encode instructions for making a specific RNA or protein, so they are “noncoding” The protein component of telomerase is called TERT 5 9/21/10 Telomere = DNA at ends of chromosomes Telomerase = enzyme that can synthesize the 5’ ends of lagging strands during replication, using telomeric DNA as the template. Why did this discovery merit a Nobel Prize? HUGE discovery for basic science   implications for human medicine http://nobelprize.org/nobel_prizes/medicine/laureates/2009/press.html Telomeres and Telomerase The initial discoveries Elizabeth Blackburn and Jack Szostak discovered the protective functions of telomeres. Carol Greider, as a graduate student in Elizabeth Blackburn’s lab, isolated telomerase from Te...
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