Cellular environmental question ph salt concentration

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Unformatted text preview: ion. Cellular environmental question. pH Salt concentration temperature …..> Abnormal environment ….> figure below. 3D structure of proteins is held together by non-covalent bonds Proteins can therefore be denatured Chaperone proteins help proteins fold (see figure 5.23 – Campbell) Sequence of amino acid dictates what they can renature, 2:45 04-09-13: Lecture 3 Proteins are agents of molecular specificity! R – group (20 different side chains) – There is an R-group to transact any chemical reactions!!! Need a positive charge Need a negative charge They can all fecilitate the following Need a H-Bond Need a hydrophobic partner etc. Proteins can have a net charge: typically dictated by R-group at physiological pH. Consider Tyr-Asp-Val at pH 7 NH3 04-09-13: Lecture 3 Proteins are agents of molecular specificity! Glucose Galactose RECOGNITION and the ability to BIND SPECIFIC MOLECULAR STRUCTURES is central to protein function!! Small molecule recognition Large molecule recognition In both case - done by placing the amino acid r groups in just the right place to optimize. form a pocket Create an interface or surface 04-09-13: Lecture 3 Proteins are agents of molecular specificity! Use of small molecule recognition Sugar molecule Sugar binding site Ex. Lectins are proteins that bind specific sugars Place 1 By ligand Transportation Place 2 04-09-13: Lecture 3 Proteins are agents of molecular specificity! Use of small molecule recognition outside cell Transport Inside cell What might be a mechanism to transport to the cell? I...
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