2007_BIO201_lecture_29

2007_BIO201_lecture_29 - BIO201A Cell Biology Lecture 29...

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Unformatted text preview: BIO201A Cell Biology Lecture 29 Wednesday 04/04/07 Important Announcements: – Next exam will be the Final given on May 8th. 34 questions over section 3 and 14 lab questions. – Final exam is 11:45AM to 2PM in four rooms: NSC 201, NSC 218, Norton 112 and OBrian 109. Information later on which room you will need to use. – Exam 2 scores are posted to UBLearns. – Exam 2 key and responses will be posted soon. Synthesis of proteins on RER Signal sequence: Leads nascent protein to the RER and through the translocon 1. It is represented by 6-10 non-polar amino acids near the end of a nascent protein 2. It targets nascent proteins for the RER 3. It is required for cotranslational translocation. This process requires: A. Signal recognition particle (SRP) B. Translocon channel C. GTP hydrolysis to provide the energy for translocation 4. In the RER, the completed protein is modified by chaperones and other factors to put it in its proper conformation and structure Synthesis of integral membrane proteins on RER Note: Steps 1 through 3 are the same as in fig. 8-12, but the SRP and SRP receptor aren’t shown. See Steps 1 through 3 are the same as in fig....
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This note was uploaded on 04/08/2008 for the course BIO 201 taught by Professor Janicke during the Spring '08 term at SUNY Buffalo.

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2007_BIO201_lecture_29 - BIO201A Cell Biology Lecture 29...

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