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Unformatted text preview: Blum et al (2009). Dev. Dyn.238:1215–1225 Mammals have cilia in the node Gilbert 9e, Fig. 8.35 Clues that humans require nodal cilia: Karatagener’s Triad •Kartagener’s triad: ~50% situs
inversus totalis. •Males have immotile heart sperm. •All patients have respiratory problems
due to mucus
accumulation in the
bronchi and lungs. http://pictures.doccheck.com/de/photos/10204/4888/situs-inversus/ Karatagener’s Triad results from loss of outer dynein arms
normal PCD •Kartagener’s triad is often called primary ciliary dyskenesia
•It results from loss of outer dynein arms, leading to immotile cilia
and ﬂagella http://upload.wikimedia.org/wikipedia/commons/thumb/7/79/
Kartagener.svg/1000px-Kartagener.svg.png Flow occurs in other vertebrates Blum et al (2009). Dev. Dyn.238:1215–1225 L/R dynein mutants misexpress Pitx2 L/R dynein is require...
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This note was uploaded on 11/08/2013 for the course ZOOLOGY 470 taught by Professor Hardin during the Fall '12 term at Wisconsin.
- Fall '12