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Unformatted text preview: et al (2007).
3893-3904. Blum et al (1999).
1225-1234 Chick: Nodal regulates the location of Pitx2 Piedra et al (1998).
Cell 94, 319–324 Nodal mRNA Pitx2 mRNA
Conclusion: Nodal induces
Pitx2 expression later Nodal cilia in ﬁsh are in Kupffer’s vesicle Kupffer’s vesicle comes from dorsal forerunner cells (special
cells that do not involute during gastrulation). They are ciliated
Gilbert 9e, Fig. 7.49 Removing cells that make Kupffer’s vesicle
frequently results in L/R reversals
Normal L KV precursor cells removed heart
mesoderm notochord Conclusion: Kupffer’s vesicle is
necessary for L/R speciﬁcation
Essner et al (2004). Development 132, 1247-1260 R Cilia are found in axial structures in all vertebrates
roof plate mammals: posterior node/notochord
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This note was uploaded on 11/08/2013 for the course ZOOLOGY 470 taught by Professor Hardin during the Fall '12 term at Wisconsin.
- Fall '12