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Unformatted text preview: d for intraﬂagellar transport
(IFT). IFT transports material to and from the tips of
cilia, and is required for their maintenance. iv mutant mice
are mutant for this dynein, and have laterality defects.
Blum et al (1999). Development 126, 1225-1234 KIF3B mutants have abnormal cilia KIF3B is a kinesin required for intraﬂagellar transport
(IFT). IFT transports material to the tip of cilia, and is
required for their maintenance.
Hirokawa (2000). Trafﬁc1:29-34 KIF3B mutants express lefty2 bilaterally
wildtype kif3b knockout lefty2 is a marker for the left side
Conclusion: cilia are needed for
development of left-right asymmetry.
Nonaka et al (1998). Cell 95:829-837 KIF3B mutants have abnormal ﬂow
KO Text kif3b knockouts have no ﬂow.
Conclusion: cilia are necessary for nodal ﬂow.
Hirokawa (2000). Trafﬁc 1:29-34 Overriding normal ﬂow can reverse the L...
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This note was uploaded on 11/08/2013 for the course ZOOLOGY 470 taught by Professor Hardin during the Fall '12 term at Wisconsin.
- Fall '12