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Ift transports material to and from the tips of cilia

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Unformatted text preview: d for intraflagellar transport (IFT). IFT transports material to and from the tips of cilia, and is required for their maintenance. iv mutant mice are mutant for this dynein, and have laterality defects. Blum et al (1999). Development 126, 1225-1234 KIF3B mutants have abnormal cilia KIF3B is a kinesin required for intraflagellar transport (IFT). IFT transports material to the tip of cilia, and is required for their maintenance. Hirokawa (2000). Traffic1:29-34 KIF3B mutants express lefty2 bilaterally wildtype kif3b knockout lefty2 is a marker for the left side Conclusion: cilia are needed for development of left-right asymmetry. Nonaka et al (1998). Cell 95:829-837 KIF3B mutants have abnormal flow WT kif3b KO Text kif3b knockouts have no flow. Conclusion: cilia are necessary for nodal flow. Hirokawa (2000). Traffic 1:29-34 Overriding normal flow can reverse the L...
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This note was uploaded on 11/08/2013 for the course ZOOLOGY 470 taught by Professor Hardin during the Fall '12 term at Wisconsin.

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