Unformatted text preview: /R axis
Axis often reversed Nonaka et al (2002). Nature 418:96-99 Overriding ﬂow can reverse the L/R axis as often as
~50% of the time. This is similar to primary ciliary dyskenia.
This also suggests nodal ﬂow may be crucial in mammals. Model: normal ﬂow in the node Model: nodal vesicular parcels (NVPs) transport materials
to the left side of the Node. This triggers signaling there
that leads to L/R asymmetries.
Gilbert 9e, Fig. 8.35 Calcium is
the left side of
the node Gilbert 9e, Fig. 8.35...
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- cilia, Situs inversus, nodal cilia, Gilbert 9e, Nodal mRNA, situs inversus totalis