Metatarsal tibiabula femur cooper et al 2011 science

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: . metatarsal tibia/fibula femur Cooper et al (2011). Science 32, 1083. digit FGF8 + Wnt3a ➔ distal digit Wnt3a and FGF8 act as proliferation signals, but result in digits (distal elements only). Other proximal limb elements are missing. Cooper et al (2011). Science 32, 1083 RA+ FGF8 + Wnt3a ➔ “normal” digit metatarsal tibia/fibula femur A source of retinoic acid (RA) is necessary for proximal limb elements in reconstituted limbs. Cooper et al (2011). Science 32, 1083 Proximal-distal outgrowth may involve a balance of signals RA FGF proximal distal A balance of FGF (distal) and RA (proximal) signals may pattern the limb along the P-D axis. adapted from Gilbert 9e,...
View Full Document

This note was uploaded on 11/08/2013 for the course ZOOLOGY 470 taught by Professor Hardin during the Fall '12 term at Wisconsin.

Ask a homework question - tutors are online