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Unformatted text preview: . metatarsal tibia/ﬁbula femur
Cooper et al (2011). Science 32, 1083. digit FGF8 + Wnt3a ➔ distal digit Wnt3a and FGF8 act as proliferation signals, but result in digits
(distal elements only). Other proximal limb elements are missing.
Cooper et al (2011). Science 32, 1083 RA+ FGF8 + Wnt3a ➔ “normal”
A source of retinoic acid (RA) is necessary for proximal limb
elements in reconstituted limbs.
Cooper et al (2011). Science 32, 1083 Proximal-distal outgrowth may
involve a balance of signals
RA FGF proximal distal A balance of FGF
(distal) and RA
may pattern the limb
along the P-D axis. adapted from Gilbert 9e,...
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This note was uploaded on 11/08/2013 for the course ZOOLOGY 470 taught by Professor Hardin during the Fall '12 term at Wisconsin.
- Fall '12