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Practice+Exam+3-11+Dec+2006

Practice+Exam+3-11+Dec+2006 - Toxicology 225 Practice...

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Toxicology 225; Practice Exam #3; 11 December 2006 Select the one best answer. 1. A synthetic peptide (16K daltons, effective molecular radius 18 Angstoms) that avidly binds cocaine (Kd=10 -9 M) is being developed as an IV drug to be used in humans for acute cocaine overdose. Initial clinical trials showed that the peptide was rapidly excreted unchanged in the urine with a half-life of 15 minutes. This extremely rapid elimination prevented efficient binding to serum cocaine. Assuming glomerular filtration is determining elimination rate, which of the following would be the most effective in increasing the serum t 1/2 of the synthetic peptide? A. Increase the molecular radius by adding basic amino acids to the peptide. B. Increase the molecular radius by adding acidic amino acids to the peptide. C. Increase the molecular radius by adding neutral amino acids to the peptide. D. Decrease the molecular radius by eliminating acidic amino acids from the peptide.
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