13. BIOS 281 Electrolyte Balance Urinary 3.0

Early distal tubule transport of ions based on

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ot permeable to water, permeable to some ions (Na and Cl) •  Thick ascending loop of Henle is hypoosmo=c •  Na, K, Cl, ions are reabsorbed by secondary ac=ve transport •  Concentra=on gradient drives reabsorp=on of Mg, Ca •  Buffering •  Aldosterone promotes Na and Cl reabsorp=on in the ascending limb –  What does this do to urine? •  Early distal tubule: transport of ions based on physiological state •  Late distal tubule: buffering based on hormones, water reten=on based on hormones •  Medullary collec=ng duct: further concentra=on of urine in most cases (depending on physiological state and hormones) Be able to label this very thoroughly! Vasopressin/ADH •  Regulates body reten=on of water: released when body is dehydrated (high osmo=c pressure) •  In kidney, leads to increased urine osmolarity (concentra=on) and decreased water loss by: –  Increasing water permeability at distal tubule and collec=ng duct •  Inser=on of water channels (aquaporin- 2) –  Increasing permeability of inner medullary por=on of collec=ng duct to urea by regula=ng the cell surface expression of urea transporters •  Facil...
View Full Document

This note was uploaded on 11/14/2013 for the course BIOSC 281 taught by Professor Varamini during the Fall '13 term at Biola University.

Ask a homework question - tutors are online