LECTURE 5 and 6 Lipids

1999 stimulated rat skeletal muscle to contractfatty

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Unformatted text preview: an additive effect...other transporters such this one, you dont see as much Jain et al. 2009 Effects of Exercise on Fatty Acid Transporters in Skeletal Muscle Bonen et al. 1999 stimulated rat skeletal muscle to contract...fatty acid transporter went up a low 7 days of chronic stimulation 7 days of CES Effects of Exercise on Fatty Acid Transporters in 1 hour/day @ 65% Skeletal Muscle in Humans VO2max, 9 days lower number here means more fat oxidation better ability to oxidize fat than in pre training more CD36 transporter Tunstall et al. 2002 Exercise induces fatty acid transporter translocation to plasma membrane in skeletal muscle in humans Bradley et al 2012 shows an acute bout of exercise moves transporter pools from in the muscle to the membrane 2 h cycling at 60% VO2peak Take home point: During exercise FAT/CD36 (and possibly FABPpm) move from intracellular depots to the plasma membrane to facilitate increased FFA uptake. FFA are then catabolized to generate ATP to match the demand of exercise. Response of fatty acid transporters to exercise appears to be similar to that of GLUT4 Co-ordinated regulation of both GLUT4 and FAT/CD36 ensures adequate uptake of fuel to the working muscles 3) Mitochondrial membrane transport FA entry into the mitochondrion is a complex process! •  Minimally, requires carnitine palmitoyl transferase1 (CPT1) as well as the substrate carnitine •  Fatty acyl CoA gets c...
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