LECTURE 5 and 6 Lipids

Fatcd36 fatty acid translocase appears to be most

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Unformatted text preview: muscle cell Protein-mediated sarcolemmal fatty acid transport into muscle What are the identified like GLUT4 but for fats FA transporters in muscle? •FAT/CD36 - fatty acid translocase – appears to be most important •FABPpm - fatty acid binding protein (plasma membrane), a peripheral protein i.e. *does not span the membrane Schenk at el 2010 •FATP1-6 – family of h#p://www.sciencedirect.com/science/ar>cle/ pii/S0952327810000736 possibility: fatty acid transporters possibility diffusion Regulation of transporter movement to membrane EXERCISE insulin mediated to bring fatty acid receptors to membrane remember: for carbs, 2 mechanisms bring GLUT4 to the membrane Interestingly, there are many similarities between the regulation of glucose and fatty acid transporters e.g. both can be translocated to plasma membrane by insulin and contraction! Two separate pools of FAT/CD36 translocate in response to insulin and exercise insulin+contraction additive not additive Take home point: Insulin and contraction stimulate fatty acid transport in an additive manner. This increase in transport is facilitated by fatty acid transport proteins. seems to be mostly transporter CD36 were you see...
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