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Goodpaster et al j clin endocrinol 86 5755 5761 2001

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Unformatted text preview: cose disposal Lots of IMTG take home point: trained athletes have almost as much lipids in their muscle as ppl with type II diabetes (less than obese individuals) BUT have the best ability of the muscle to dispose of glucose through oxidation ability of muscle to dispose of glucose BUT insulin sensi2ve ! Goodpaster et al. J Clin Endocrinol 86: 5755-5761, 2001 IMTG as a fuel source during exercise Van loon, 2004 Regulating the "Blend" of Fat and Carbohydrate Utilized During Exercise Increasing FA availability during exercise can generally induce glycogen sparing, over a range of intensities e.g. 40 to 90% VO2max HOW might you do this? • Triglyceride emulsion (e.g. Intralipid) infused into the arm vein during exercise • Caffeine ingestion, ~ 5 to 9 mg/kg body mass • Aerobic/endurance training! Glycogen utilization is typically around 40% less than in the control trial (i.e. glycogen sparing), and occurs in the first 20 min of exercise, when glycogen breakdown is fastest What about during recovery from exercise … switch to utilization of fat for energy Why? Protect carbohydrate stores – need to replenish! This seems to be a metabolic priority! How? Lots of plasma FFA right after exercise enzyme that converts pyruvate to acetyl-coA PDH seems to be down-regulated - so glucose oxidation is reduced, allowing redirection towards glycogen synthesis. Are IMTG a source? Most studies indicate no… probably trying to replenish IMTG too...
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