LECTURE 5 and 6 Lipids

E cant get enough albumin to adipocyte to bind the

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Unformatted text preview: ipose tissue: •  Impaired during high intensity exercise due to reduced blood flow to adipose tissue •  i.e. can't get enough albumin to adipocyte to bind the released FFAs (remember that fatty acids must be bound!) •  this may be part of the reason for the observed reduction in fat utilization at high intensities (e.g. above 65% VO2 max) remember that carbohydrate becomes more important fuel at high intensity exercise Q: Can you increase the rate of fat oxidation at high intensities if you could somehow increase the amount of FFA in the blood? A: YES! Some evidence for this: We will further discuss strategies later in the course… Infusing Intralipid (a TAG emulsion) in subjects cycling at 85% VO2max increased fat oxidation by 27%! (Romijn et al. J Appl Physiol. 79(6): 1939-1945, 1995) 2) Fatty Acid Uptake into Skeletal Muscle Exercise and Lipoprotein Lipase in Skeletal Muscle 6 subjects, cycled at 65% VO2 max, 1 h Increased total amount of LPL in muscle cleaves fatty acid and allows it to enter the muscle Greiwe et al. 2000 What does this do? Ensures increased flux of fatty acids to contracting muscle plasma membrane of...
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This note was uploaded on 11/14/2013 for the course NUTR 4210 taught by Professor Guelphuniversity during the Fall '13 term at University of Guelph.

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