LECTURE 5 and 6 Lipids

E that cpti was rate limiting for fa entry into

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Unformatted text preview: onverted to fatty acyl carnitine, which can move across the mitochondrial membrane this form gets it into mitochondrial membrane This was the dogma until only a few years ago i.e. that CPTI was rate limiting for FA entry into mitochondria Recently, it was discovered that FAT/CD36 is also present on the mitochondrial membrane - the details/significance of this are not entirely clear yet - but the complexity is increasing! AMP-activated protein kinase (AMPK) - an important regulator of fat metabolism? take home point: by lowering malonyl coA conent in skeletal muscle, the inhibitory effect on CPT1 is diminished and entry of acylated fatty acids into the mitochondria is facilitated malonyl coA decarboxylase acetyl coA carboxylase (ACC) is inactivated by AMPK (from exercising) requires carnitine *occurs in mitochondria 4) Mitochondrial Fat Oxidation "rate limiting" enzymes, typically β hydroxyacyl dehydrogenase we've said before that the ability to oxidize fat is enhanced with exercise training -Exercise training induces mitochondrial biogenesis •  (βHAD, in β oxidation), citrate synthase (CS, in Krebs cycle) and cytochrome oxidase (in ETC), as well as CPTI, are markedly increased in exercise-trained vs. untrained individuals •  these are "cl...
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This note was uploaded on 11/14/2013 for the course NUTR 4210 taught by Professor Guelphuniversity during the Fall '13 term at University of Guelph.

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