LECTURE 5 and 6 Lipids

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Unformatted text preview: to be mobilized to use during exercise diglyceride h#p://edrv.endojournals.org/content/23/2/201/F1.large.jpg 1) Mobilization of FFA from adipose tissue To be used as fuel! start HSL Review: What is the fate of fatty acids in adipose tissue? 1) Release, 2) Re-esterification (storage), 3) Oxidation at rest we are oxidizing fatty acids for energy HSL / TG interaction – role of perilipins? TG Epi What are Perilipins? •  protein coating that surrounds TG in adipocyte •  a "protective barrier" preventing HSL docking (i.e. blocks lipolysis) •  phosphorylated by protein kinase A (PKA), causing movement away from droplet •  PKA also phosphorylates and activates HSL Thus, 2 levels of control - i) HSL activation, ii) removal of perilipin barrier to permit HSL "docking” Effects of Exercise on Adipose Tissue Lipolysis higher activity=more Enevoldsen et lipolysis In a rat study, 18 wks of swim training (black bars) increased amount of HSL and sensitivity of HSL to stimulation by Epi (5 min or 20 min) in adipose tissue (differences between fat depots). In contrast, in skeletal muscle (not shown here) amount of HSL was unchanged and its sensitivity to Epi stimulation was reduced after exercise training. al. J Physiol. 2001 this affect of increasing HSL activity was ONLY on adipose tissue, not muscle Exercise and FFA release from ad...
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This note was uploaded on 11/14/2013 for the course NUTR 4210 taught by Professor Guelphuniversity during the Fall '13 term at University of Guelph.

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