LECTURE 5 and 6 Lipids

He level in the plamsa and arriving at the muscles in

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: t the contribution from plasma FFAs is THAT impaired in the trained state: Plasma levels might be lower in trained individuals, but trained muscle has more fatty acid transporters - thus there is better extraction from the blood!he level in the plamsa and arriving at the muscles in trained individuals is t LOWER, but these individuals have more transporters so the fatty acids that arrive at the musle have a better chance of being transported into the cell, having more fatty acids available to be oxidized Summary of mechanisms that might explain an exercise training-induced increase in reliance on fat oxidation increase in mitochondrial biogenesis •  ↑ mitochondria - means more "powerhouses" to deal with sudden increase in need for ATP •  less “disturbance” of energy charge (i.e. smaller: ↓ATP/ ↑ADP, AMP, Pi) --> this should lead to less activation of glycogen phosphorylase and thus allow glycogen sparing •  ↑ FA transport (more FAT/CD36 and FABPpm in membrane) first 3 are the most important •  ↑ IMTG content (next slide!) •  ↑ muscle HSL activation ? •  less sensitivity to malonyl CoA inhibition? •  ↑ adipose tissue HSL … no, not a factor intramuscular triglycerides IMTG associated with insulin resistance: a paradox in endurance trained athletes? trained athletes have more lipid in their muscle...similar to individuals with type 2 diabetes M = glu...
View Full Document

This note was uploaded on 11/14/2013 for the course NUTR 4210 taught by Professor Guelphuniversity during the Fall '13 term at University of Guelph.

Ask a homework question - tutors are online