Membraneisabilayerofphospholipids

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Unformatted text preview: ive Ion transport: keeps potassium in & sodium out ► Prevents osmotic hemolysis ► ATP required RBC membrane lipids RBC membrane lipids ► Membrane is a bilayer of phospholipids interspersed with cholesterol ► Phosphatidylcholine and sphingomyelin – outside layer ► Phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine – inner layer Target cells and Acanthocytes Target cells and Acanthocytes Hemoglobin Hemoglobin Synthesis of protoporphyrins Synthesis of protoporphyrins Hemoglobin synthesis Hemoglobin synthesis Globin genes Globin genes Siderocytes Siderocytes Hemoglobin function: maintained Hemoglobin function: maintained by red blood cell metabolism ► Healthy metabolism is required to generate ATP ► Glycolysis is the main pathway used by RBCs to generate ATP ► Mature RBCs have no mitochondria – they are anaerobic ► Three other metabolic pathways are also important to maintaining hemoglobin function Heinz bodies Heinz bodies Erythrocyte senescence and Erythrocyte senescence and hemolysis ► Red blood cells circulate in blood 120 days ► 1% of all RBCs are removed daily due to aging ► Removed by phagocytes in the spleen ► Modifications to RBC membrane facilitate removal ► Bone marrow replaces 1% of RBCs daily Extravascular hemolysis Extravascular hemolysis Intravascular hemolysis Intravascular hemolysis...
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This document was uploaded on 11/16/2013.

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