Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ive Ion transport: keeps potassium in & sodium out ► Prevents osmotic hemolysis ► ATP required RBC membrane lipids RBC membrane lipids ► Membrane is a bilayer of phospholipids interspersed with cholesterol ► Phosphatidylcholine and sphingomyelin – outside layer ► Phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine – inner layer Target cells and Acanthocytes Target cells and Acanthocytes Hemoglobin Hemoglobin Synthesis of protoporphyrins Synthesis of protoporphyrins Hemoglobin synthesis Hemoglobin synthesis Globin genes Globin genes Siderocytes Siderocytes Hemoglobin function: maintained Hemoglobin function: maintained by red blood cell metabolism ► Healthy metabolism is required to generate ATP ► Glycolysis is the main pathway used by RBCs to generate ATP ► Mature RBCs have no mitochondria – they are anaerobic ► Three other metabolic pathways are also important to maintaining hemoglobin function Heinz bodies Heinz bodies Erythrocyte senescence and Erythrocyte senescence and hemolysis ► Red blood cells circulate in blood 120 days ► 1% of all RBCs are removed daily due to aging ► Removed by phagocytes in the spleen ► Modifications to RBC membrane facilitate removal ► Bone marrow replaces 1% of RBCs daily Extravascular hemolysis Extravascular hemolysis Intravascular hemolysis Intravascular hemolysis...
View Full Document

This document was uploaded on 11/16/2013.

Ask a homework question - tutors are online