L6 Antibiotics and Bacterial Resistance

Blogspotca 15 normal pep doglycan assembly penicillin

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Unformatted text preview: side •  Transglycosylase brings together the building block and the growing chain •  Transpep=dase a[aches the amino acid cross- link from one chain to another 12 Unit 3: How does penicillin work? Mechanism of penicillin ac-on- the key players PENICILLIN BIOLOGY 1A03 Cellular and Molecular Biology TRANSPEPTIDASE 14 Normal pep-doglycan assembly BIOLOGY 1A03 Cellular and Molecular Biology + Peptidoglycan building blocks = cross-linked peptides http://sbftm.blogspot.ca 15 Normal pep-doglycan assembly + penicillin BIOLOGY 1A03 Cellular and Molecular Biology Penicillin interacts with Transpeptidase and inhibits the peptide cross-linking http://sbftm.blogspot.ca 16 Normal pep-doglycan assembly + vancomycin BIOLOGY 1A03 Cellular and Molecular Biology Vancomycin binds to and blocks the peptide binding site for transpeptidase, thus inhibits the peptide cross-linking http://sbftm.blogspot.ca 17 Mechanism of penicillin and vancomycin ac-on BIOLOGY 1A03 Cellular and Molecular Biology http://sbftm.blogspot.ca 18 There are many ways that an-bio-cs can kill bacteria 1.  Interfering with cell wall synthesis 2.  Disrup=ng bacterial protein synthesis at the ribosome 3.  Inhibi=ng the func=on of enzymes needed for DNA Cellular and Molecular synthesis BIOLOGY 1A03 Biology 19 Unit 4: Bacteria can be resistant to an=bio=cs Th...
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This note was uploaded on 11/21/2013 for the course BIOLOGY 1A03 taught by Professor Dr. kajiura during the Fall '10 term at McMaster University.

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