bibc 100 mt1

bibc 100 mt1 - 5-. 1 _ Name (last, first) : BIBC 100...

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Unformatted text preview: 5-. 1 _ Name (last, first) : BIBC 100 University of California, San Diego, Dr. Lukas Buehler Summer 05 YOUR SCORE: MIDTERM 1 (80 POINTS) POINTS, YOUR GRADE _ All Students please read the following waiver: By signing this waiver. I give permission for this exam to be left for me to pick up in Bonner Hall 2238. If I do not sign this waiver, I acknowledge that my exam will be available for pickup during office hours or class. I Signature Date PLEASE READ THE QUESTIONS CAREFULLY BEFORE ANSWERING! 1. What glycosidic bond is commonly found in structural homo-polysaccharides the form elongated fibers? ( 5 points Q) H) Name two unbranched homo-polysaccharide and their monosaccharide building blocks that fit this description. 0. QilkIO It We 092; ISM MIG] 2. Name two common phospholipids with zwitterionic headgroups. ire, l’c 5 points What is the net charge at physiological pH of the phospholipid that carries a common amino acid in its headgroup? ' —— r 3. What is the relationship between the saturationfdesaturation level of phospholipids and the melting temperature of a lipid bilayer? 10 points +€q HEM} If you could choose between palmitic acid @, which one would make for a bilayer with a lower melting temperature if used in p sp olipids? (Circle your choice) I 2 ' Name (last, first) : I 6. What does the ‘K’ stand for in pK of an acid-base reaction? 4. Draw a hydration shell with four water molecules around a sodium ion. Indicate the orientation of the water dipole moments and presence of hydrogen nd between water molecules, if any, A _ Spomts xiii \ 6‘4“ _ (3/ / >§K [/10 loyalme l>aM helmet“ Mai/AW Wicca/.0) 5. Which macroscopic property used in Coulomb’s law is a good measure of the solubility of a chargedf polar solute in a solvent? 10 points Dis, [who L Cmfl—M'l’ What related microscopic property does a solute have that is readily soluble in water? ozipdlt View/"Ml (“I”) Name one amino acid that with a side chain structure having said microscopic property and which contributes to the water solubility of a protein, but carries noXcharges at physiological pH (when not part of the N or C terminus). _. M g. ‘1’ ¥ LN“ TOMA r {we Rko g ‘ l i M! oLK C! 7t V bro-wpo bfll’l‘ufie 5 points ,, [MM] .. - EEK-«Tion w: 3 Name (last, first) : 7. Draw a Ramachandran plot for the backbone structure of an alpha! beta protein. Label the axes of the plot and circle the approximate position of expected torsion angle values in such a protein. 10 points 8. You design a small, water-soluble, four-helical bundle protein. What sequence rule would you apply to choose an appropriate amino acid sequence for the individual helices in the protein? Some peptide chemists don’t rely on this rule but use a graphical method. Name this method. 5 points vx + 1,” Wall M 9. Describe the relationship between the base pair content of a DNA sample and its melting temperature? (Use words or a graphic) 10 points 6H; mlLJr ii la Tm s all / ' \k 4 Name (last, first) : 10. Which enzyme class matches amino acids with tRN As essentially performing the task of translator of the genetic code? 5 points was OU/ia’i JrMfi SVJMMN (59PM) These enzymes contain two active sites? What are their general functions? Whit/{Re m0“; NC twlfixg’is REL) ALP-H“? 11M 0‘4.“ l 1. Draw a topology diagram of a transfer RNA molecule and name the four domain structures that have been identified. Which of these domains appear to be separate, but really interact via base-pairing in the folded tRNA molecule? 10 points aowg‘i“ m Dc” —J W ...
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bibc 100 mt1 - 5-. 1 _ Name (last, first) : BIBC 100...

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