bicd 140 final

bicd 140 final - Name:_____________________ 1 Student ID #...

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Unformatted text preview: Name:_____________________ 1 Student ID # ___________ BICD 140 Spring 2007 Final Exam Please write your name on each page and look through your exam. It should have 12 pages. Do not use pencil or white out on your exam. Be certain that all of the work that you want graded is written in permanent ink. Your score Short Answer A, 10 points possible ________ Scantron 82 points possible ________ Short answer B-E, 18 points possible ________ Short answer F-I, 22 points possible ________ Correctly filling out scantron 1 pt ________ Total possible 133 points. ________ You may sign below to signify that you have given your permission for your exam to be distributed in a way that may subject it to public scrutiny. If you sign below your grade will be posted by student ID on the website. Signature_____________________ I pledge not to cheat, plagiarize, steal, or lie in matters related to academic work. Signature_____________________ Name:_____________________ 2 Short answer: A. Recently the causative agent of Senioritis, a syndrome including general malaise, shortening of attention span and a desire to go to the beach, has been isolated. It turns out that it is caused by a mycobacterium which takes up residence in phagocytes. Fortunately, most individuals make a robust immune response and clear the infection by the time their jobs start in September. Outline the sequence of events leading from infection to the adaptive response leading to the clearance of the Senioritis bacteria. Include critical cell-cell interactions and their anatomic locations. Keep your answer to the space below and think about the important cell that provides a link between innate and adaptive immune responses. Include two types of receptors relevant for the activation of innate immunity and two receptor/ligand pairs relevant for the activation of adaptive immunity, relevant cytokines produced by innate and adaptive cell types and the cell types and molecules that are necessary for elimination of the bacteria. Write your answer in chronological order and keep in mind that how well you present your answer will be part of the grade. 10 pts. 1 pts for each: macrophage/neutrophils activated dc activated via TLR, C receptor, etc. TNF and IL-1, IL-6 migration of dc to LN prime T cells/ B7/CD28 TCR/MHC which help b cells make opsonizing abs. return to site activate macrophages to kill the bacteria by IFNgamma production or CD40L Name:_____________________ 3 Note: you get one point for filling out your scantron completely and correctly. True/False: on your scantron, use a for true and b for false. 1. The lymphoid follicle within a lymph node contains mostly B cells. A 2. Developing B and T cells each require expression of surrogate antigen receptor chains to test for heavy and beta chain rearrangements, respectively. A 3. The adaptive immune system is essential for an organism to survive in the world. B 4. Commensual bacteria defend against infection by suppressing the immune system. B Commensual bacteria defend against infection by suppressing the immune system....
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This test prep was uploaded on 04/07/2008 for the course BICD 140 taught by Professor Goldrath during the Spring '07 term at UCSD.

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bicd 140 final - Name:_____________________ 1 Student ID #...

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