Microbiology Day 14 - Microbiology March 5th Slide2...

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Microbiology March 5 th Slide2 Homologous recombination have similar or the same DNA sequence at the point of exchange. This happens for a lot of reasons, in mitosis in eukaryotes, where you exchange one strand or both strands exchange. So you can exchange a whole section and in this slide, a nick is one strand, which is caused by an endonuclease. So it recognizes sequences and cuts the bond, making a nick, SSB comes in and binds to the ss DNA strand. This is one example of recombination and there is many. You get RecA protein (and others) which brings nick strand into homologous strand of other DNA, attaches them and by displacing the top strand. So you replace one strand with the other. If there is a bit of difference, then you change the nature of the gene. The light gene is a bit different, but the point of exchange is almost identical. The crossing can continue all the way, or another resolution step can occur and displaces the strand and can stop at any point. This leads to replacing only parts of the DNA section.
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