Edited Brochure - Symptoms A person with Sickle cell anemia...

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Symptoms A person with Sickle cell anemia may experience a variety of dangerous symptoms because the disease distorts red blood cells. These sickle shaped blood cells deliver less oxygen, break down prematurely, and are more likely to clog small blood vessels. This causes certain tissues to have less blood, damaging them. One of the first signs of the disease is dactylitis, which is swelling of the hands or feet. Common symptoms of the disease are jaundice, fatigue, paleness, rapid heart rate, stomach pain, bone pain, breathlessness, delayed growth, and ulcers on lower legs. Others include chest pain, excessive thirst, strokes, skin ulcers, acute chest syndrome (caused by lung tissue damage), poor eyesight, or blindness. Nearly all people with Sickle Cell Anemia have crises, which are period of pain. Crises vary in severity, frequency, and length. Causes Sickle cell anemia is a genetic trait that is inherited from one’s parents. The allele for sickle cell anemia is an incomplete dominant trait. This means that a heterozygous person would make both healthy red blood cells and sickle shaped ones, but do not have sickle cell anemia because they have enough healthy red blood cells. However they would still pass on the allele for the disease. Sickle cell anemia is thought to have been the result of a genetic mutation that happened in malaria-prone regions long time ago because the sickle cell trait actually helps people survive from malaria. Distribution of malaria Distribution areas of sickle cell Prognosis Sickle cell anemia is an inherited, lifelong disease that varies from person to person and depends on many factors. Some
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