Lecture - Cell Communication and Energy Oct 16

Amp pde nucleus creb creb binds to a transcripon

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Unformatted text preview: and G-Protein •  conforma<onal change of G- protein coupled receptor (GPCR) causes a GDP to be removed from the associated G- protein and a GTP added to the associated G- protein •  Therefore an ac<vated G- protein has a bound GTP Cyclic AMP Signal Transduction Pathway Very common and important signal transduc2on pathway. Is associated with a G protein- coupled receptor. Cyclic AMP Signal Transduction Pathway Contains the second messenger molecule Cyclic adenosine monophosphate (cAMP or cyclic AMP) Cyclic AMP is NOT a protein It is a second messenger molecule made from ATP Conversion of ATP to cyclic AMP catalyzed by Adenylyl Cyclase Cyclic AMP Signal Transduction Pathway Signal Transduction and Transcription Control •  Protein kinase A phosphorylates CREB, thus ac<va<ng it. AMP PDE Nucleus CREB •  CREB binds to a transcrip<on factor on the DNA. •  This binding to the transcrip<on factor ini<ates DNA transcrip<on. Cyclic AMP Signal Transduction Pathway 1.  Signaling molecule binds to receptor. 2.  Receptor conforma<onal change (receptor in ac<ve form) ac<vates G protein (GDP exchanged for GTP) 3.  Ac<vated G protein travels to and ac<vates adenylyl cyclase. Cyclic AMP Signal Transduction Pathway 4.  Ac<vated adenylyl cyclase catalyzes the conversion of ATP to cyclic AMP 5.  Cyclic AMP binds to and ac<vates...
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