Lecture - Cell Communication and Energy Oct 16

The bacteria releases a toxin enzyme that prevents

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Unformatted text preview: protein kinase A 6.  Ac<vated protein kinase A phosphorylates other proteins in the cell. This leads to a response Signal Amplifica<on - cAMP hMp://highered.mcgraw- hill.com/olcweb/cgi/pluginpop.cgi?it=swf:: 535::535::/sites/dl/free/0072437316/120069/bio08.swf::Signal %20Amplifica<on Terminating the Response •  Signaling molecule removed from the receptor. Receptor returns to inac<ve conforma<on PDE •  No more G- proteins will be ac<vated. •  No more adenylyl cyclase will be ac<vated. AMP •  No more Cyclic AMP will be made and that present is converted to AMP by enzyme phosphodisesterase (PDE) •  Protein kinase A deac<vated in absence of cyclic AMP (i.e. it only works when cyclic AMP present) Terminating the Response Phosphodiesterase (PDE) – breaks cAMP to AMP Think about… What would happen if adenylyl cyclase could not be ac2vated? AMP PDE Think about… What would happen if phosphodiesterase (PDE)...
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