2.8 Module 2 Part 3 Notes for Blackboard SN2

More electronegafve atoms are weaker nucleophiles o

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Unformatted text preview: Nucleophilicity mirrors basicity in these 3 cases 2. A negaFvely charged nucleophile is always stronger than its conjugate acid OH Weaker base Weaker Nu vs O Stronger base Stronger Nu 9 Nucleophilicity mirrors basicity in these 3 cases 3. Nucleophilicity and basicity decrease going to the right on the periodic table. More electronegaFve atoms are weaker nucleophiles. O Weaker base Weaker Nu vs NH Stronger base Stronger Nu 10 Nucleophilicity is opposite to basicity in these 2 cases 1.  Steric hindrance decreases nucleophilicity Sterically hindered nucleophiles have...
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This document was uploaded on 12/08/2013.

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