Day 2 Notes Key.pdf - sciovirtual.org*Notes to take during class(Make a copy or print out Cells Osteoprogenitors differentiate into osteoblasts aka

Day 2 Notes Key.pdf - sciovirtual.org*Notes to take during...

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sciovirtual.org ***Notes to take during class! (Make a copy or print out) Cells Osteoprogenitors - differentiate into osteoblasts - aka Osteogenic cells - Found in the Osteogenic layer (aka Cambium layer found in the periosteum!) Osteoblasts - bone makers - Secretes osteoid - Unmineralized bone matrix - Made of mostly collagen - Alkaline phosphatase mineralizes osteoid - Mineralized osteoid is bone! - Synthesizes collagen - Calcitonin boosts activity - Decrease calcium blood levels - Express RANKL and osteoprotegerin - Osteoprotegerin binds to RANKL and prevents it from binding to osteoclasts Osteoclasts - bone breakers - Secretes acid phosphatase & cathepsin K - Cathepsin K digests collagen, elastin, and gelatin - Located in Howship’s lacunae - Parathyroid hormone (PTH) boosts activity - Increase calcium blood levels - RANKL allows for differentiation - Ruffled border - Increases surface area - Bone resorption - Podosomes create sealing zone
sciovirtual.org Osteocytes - control osteoblasts - Located inside lacunae -

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