Lecture 9 Immune System-2007

Lecture 9 Immune System-2007 - Inflammatory and Immune...

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Inflammatory and Immune Disorders: Part I Lecture 9 Drugs for Inflammation, Allergies, and Immune Disorders Drugs for Bacterial Infections
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Inflammation Inflammation A natural response that limits the spread of invading microorganisms A complex process Occurs in response to many stimuli Central purpose of inflammation Contain the injury Destroy the foreign agent
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Inflammation Signs of inflammation Swelling Pain Warmth Redness
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Inflammation Acute vs. Chronic Acute Injury or damaging agent is contained and symptoms begin to resolve in 8 - 10 days Chronic Inflammation may persist for years Symptoms become progressively worse over time Examples may include arthritis or lupus
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Inflammation Chemical Mediators Chemicals released by damaged tissue, a response that alarms surrounding tissue Histamine – stored & released by mast cells Leukotrienes – stored & released by mast cells Bradykinin – initiates pain response Complement – proteins, neutralize/destroy antigen
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Inflammation Histamine Produces its effect by interacting with 2 different receptors H-1 Receptors Present in vascular smooth muscle, GI, bronchi Stimulation itching, pain, edema, vasodilation and bronchoconstriction H-2 Receptors Present in the stomach Stimulation secretion of large amounts of HCl acid
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Inflammation Humoral Immunity Involves production of antibodies Antigen – foreign substance, elicits immune response Lymphocyte (B-cells) – primary cells of immune system that interact with antigens Activated B-cell clones itself (plasma cells) and produce antibodies (immunoglobulins) specific to that antigen (takes at least 10 days) Memory B-cells remember the antigen. If exposed again, body produces more antibodies, faster~2 days
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Allergy What is an allergy? A hyper-response of body defenses Signs and symptoms are similar to those of inflammation – due to histamine release Also involves mediators of the immune system
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Allergy Allergic Rhinitis Most common allergic disorder Affects 15-20% of US population Inflammatory disorder of the nasal mucosa Symptoms Sneezing, rhinorrhea (runny nose), watery eyes and nasal congestion Occurs due to release of histamine and inflammatory mediators in response to specific allergens Two forms Seasonal outdoor allergens--hay fever (spring and fall) Perennial indoor allergens, dust mites and pet
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Drugs Used to Manage Allergic Rhinitis Several Classes Oral Antihistamines (H-1 blocker) Intranasal Glucocorticoids Decongestants (sympathomimetics) Mast cell stabilizer -- Intranasal Cromolyn
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Drugs for Allergy Antihistamines H1 Receptor- Antagonists Block action of histamine at H1 receptors Relieves sneezing, rhinorrhea and nasal itching They do not relieve nasal congestion No value against common cold
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This note was uploaded on 04/08/2008 for the course HSC 201 taught by Professor Jordan during the Spring '08 term at Harper.

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Lecture 9 Immune System-2007 - Inflammatory and Immune...

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