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Pathways and Cross Talk

Pathways and Cross Talk - Pathways and Cross Talk Types of...

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Pathways and Cross Talk Types of activation through SAMS (substrate adhesion) and CAMS (cell adhesion) - RTK activation – binding to fibronectin in extracellular matrix and works through a series of adaptor proteins and kinases to turn onto our g-protein RAS. RAS acts as our signal to turn on other transcription factor. This shows that extracellular reactions don’t have to directly be related to cell movement. - “hijacking” the FGF receptor – FGF receptor can be “hijacked” by CAMS on adjacent molecule. This causes a phosphorylation process that generates a signal. - Extracellular signaling can be used for cytoskeletal interactions and movement and pathways in the cell. Direct Cellular communications – Gap junctions - Proteins consisting of hexomers called connexins. Gap junctions pass relatively small molecules. We can signal small molecules (cAMP, Ca ++ ions, electrical coupling) through these gap junctions.
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