Activation of Protein Synthesis

Activation of Protein Synthesis - Activation of Protein...

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Activation of Protein Synthesis - Recall the Na:H antiport: as one sodium comes in, one hydrogen comes out – this causes a pH shift (6.8 to about 7.8) - Very shortly after fertilization, there is a burst of protein synthesis. This occurs before the first cleavage, but continues for a very considerable amount of time. - The red graph line represents the incorporation of 14 C valine in protein. There is a peak within about 5 hours after fertilization. It levels off at 5 hours and decreases a little bit. Then there is another burst at a much later time point. This is a special point where this new burst is initiated. - Protein synthesis appears to be strictly the result of proteins being translated. No or little new RNA is being made. It is relying on the stores of internal mRNA. This mRNA is probably masked until this point. - How do we know that no new RNA is being produced? Actinomycin D treated with seawater – protein synthesis still continues to come to a peak at about 5 hours. After this time, there is a rapid decrease in protein synthesis. Actinomycin
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