100%(2)2 out of 2 people found this document helpful
This preview shows page 1 - 4 out of 17 pages.
1Drugs for Infectious DiseasesBasic Concepts of Pharmacology & Therapeutics-Part II Part II -J. Boullata, PharmD, RPh, BCNSPProfessor of Pharmacology & TherapeuticsPenn NursingDrugs for Infectious Diseases•Basic Antimicrobial Principles•Antibacterial Agents • AntifungalAntifungal AgentsAgentsAntifungalAgents •Antiviral DrugsAntibacterial Agents1.Cell wall active antibacterials–Beta-lactam antibiotics–Glycopeptide antibiotics 2I tfitht ithi2.Interfere with protein synthesis–Bactericidal versus bacteriostatic3.Interfere with nucleic acids4.Anti-metabolite antibacterialsAntibacterial Agents2. Interfere with Protein Synthesis•Bactericidal – Aminoglycosides– Cyclic lipopeptides (daptomycin)• BacteriostaticBacteriostatic– Macrolides– Tetracyclines– Others• Clindamycin, linezolid, quinupristin/dalfopristinBacterial Protein Synthesis
2Antibacterial Agents2. Interfere with Protein Synthesis•Bactericidal –Aminoglycosides– Cyclic lipopeptides (daptomycin)• Bacteriostatic– Macrolides– Tetracyclines– Others• Clindamycin, linezolid, quinupristin/dalfopristinGentamicin(Garamycin®)•Indication – serious infections caused by susceptible strains of GN bacilli•MOA – binding to 30-S ribosomal subunit to disrupt bacterial protein synthesis•Dose –based on several factors including body weight;/kIVd il(di id d d)~5-7 mg/kg IV once daily (or divided doses) •Distribution –well distributed in ECF space, crosses placenta, concentrates in renal and inner ear cells (t½ ~2 h)•Elimination – renally (unchanged)•Adverse effects –ototoxicity (auditory & vestibular), nephrotoxicity, hypersensitivity reaction; interactionpenicillins, NM blockers, oto- & nephrotoxinsGentamicinAntibacterial Agents2. Interfere with Protein Synthesis•Bactericidal – Aminoglycosides–Cyclic Cyclic lipopeptideslipopeptides• Bacteriostatic– Macrolides– Tetracyclines– Others• Clindamycin, linezolid, quinupristin/dalfopristin