Cardiovascular Pharmacology_(6 slides) - Houry Puzantian PhD MSc Pharm RN BSN Lecturer in Pharmacology Therapeutics Penn Nursing Research Fellow

Cardiovascular Pharmacology_(6 slides) - Houry Puzantian...

This preview shows page 1 - 5 out of 10 pages.

9/29/2012 1 Cardiovascular Pharmacology Houry Puzantian, PhD, MSc Pharm, RN, BSN Lecturer in Pharmacology & Therapeutics, Penn Nursing Research Fellow, Institute for Translational Medicine & Therapeutics Joseph Boullata, PharmD, RPh, BCNSP Professor of Pharmacology & Therapeutics Penn Nursing The Cardiovascular System The Cardiovascular System Cardiovascular Diseases Valvular Calcification, Stenosis Coronary Artery Disease Arrhythmias Heart Failure Cardiovascular Diseases\ Vascular Conditions Nasal Congestion Hypertension Raynaud’s Disease Outline Introduction: The Nervous System Neurotransmitters Receptors Adrenergic Agonists Adrenergic Antagonists
9/29/2012 2 Nervous System Central Nervous System Brain Spinal Cord Peripheral Nervous System Somatic Autonomic . Sympathetic . Parasympathetic . Enteric Organ Innervation Cardiovascular Innervation PNS Neurotransmitters Acetylcholine (Ach) Norepinephrine (NE) Epinephrine (Epi) Dopamine (DA) CNS Neurotransmitters Monoamines (NE, DA, 5 HT) Amino Acids (GABA, aspartate, glutamate) Peptides (opioids, somatostatin, oxytocin, neurotensin) Ach, others Neurotransmitters Receptors Epi and NE DA β 1 , β 2 , β 3 α 1 , α 2 D 1 , D 2 Adrenergic Dopaminergic Adrenergic Receptor
9/29/2012 3 Distribution of Adrenergic Receptor Subtypes α 1 Postsynaptic smooth muscle (contraction) (contraction) α 2 Presynaptic neurons, postsynaptic tissues (ocular, adipose, intestinal, hepatic, renal, endocrine) and platelets β 1 Heart (stimulation) β 2 Bronchial, uterine, vascular smooth muscle (relaxation) β 3 Lipolysis in adipose tissue Functions of Adrenergic Receptors α 1 : Eyes (arteriolar constriction, radial muscle contraction ‐‐ > pupil dilation: mydriasis) Arterioles (constriction) Veins (constriction) Male sex organ (ejaculation) Urinary bladder neck (contraction) α 2 : Presynaptic nerve terminals (inhibit transmitter release) Functions of Adrenergic Receptors β 1 : Heart (stimulation) Increased rate Increased force of contraction Increased AV conduction velocity Kidney (Renin release) β 2: Arterioles (Dilation) Bronchi (Dilation) Uterus (Relaxation) Liver (Glycogenolysis) Skeletal Muscle (Contraction, Glycogenolysis) D 1 : Kidney (Renovascular Dilation) Adrenergic Receptor Agonists Adrenergic receptor activators \ Sympathomimetics Mechanisms of Action Chemistry Receptor Specificity Receptor Effects Adrenergic Agonists Mechanisms of Action Direct Receptor binding (Epinephrine, Dopamine) Indirect Increased NE release (Amphetamines) Blocked NE reuptake (Tricyclic antidepressants) Inhibited NE deactivation (MAO inhibitors)
9/29/2012 4 Chemical Structure