Notes on Scaffolds

Scaffolds which act as temporary substrate facilitate

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Unformatted text preview: Scaffolds, which act as temporary substrate, facilitate necessary support for cells to proliferate and to maintain differentiated function of the cells, are major component among various strategies such as cell-based and factor-based strategies [9]. The success of bone tissue engineering depends on the performance of the scaffolds [9]. Some requirements exist that a successful scaffold for bone tissue (or osseous tissue) engineering must meet [9]: 1. Osteoconductivity: The porous interconnected structure permitting new cells to attach, proliferate, and migrate through the structure and also allows for the exchange of nutrient-waste as well as new blood vessels penetration; 2. Osteoinductivity: Having the quality for possessing the necessary proteins and growth factors which can induce the progression of mesenchymal stem cells and other osteoprogenitor cells toward the osteoblast lieage; 3. Osteogenecity: The osteoblasts which are present at the site of new bone formation that can produce minerals to calcify the collagen matrix to form the substrate for new bone; 4. Osteointegration: The newly formed mineralized tissue must be able to form an intimate bonding with the implant material [40]; 5. Biocompatibility: The lack of immunogenic response. The scaffold should be made of a material with appropriate rate of degradation in order to allow the surrounding tissue eventually replace the scaffold [1]; 6....
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This note was uploaded on 01/12/2014 for the course MECH 810 taught by Professor Various during the Fall '13 term at Queens University.

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