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Unformatted text preview: Scaffolds, which act as temporary substrate, facilitate necessary support for cells to
proliferate and to maintain differentiated function of the cells, are major component
among various strategies such as cell-based and factor-based strategies . The success
of bone tissue engineering depends on the performance of the scaffolds .
Some requirements exist that a successful scaffold for bone tissue (or osseous tissue)
engineering must meet :
1. Osteoconductivity: The porous interconnected structure permitting new cells to
attach, proliferate, and migrate through the structure and also allows for the
exchange of nutrient-waste as well as new blood vessels penetration;
2. Osteoinductivity: Having the quality for possessing the necessary proteins and
growth factors which can induce the progression of mesenchymal stem cells and
other osteoprogenitor cells toward the osteoblast lieage;
3. Osteogenecity: The osteoblasts which are present at the site of new bone
formation that can produce minerals to calcify the collagen matrix to form the
substrate for new bone;
4. Osteointegration: The newly formed mineralized tissue must be able to form an
intimate bonding with the implant material ;
5. Biocompatibility: The lack of immunogenic response. The scaffold should be
made of a material with appropriate rate of degradation in order to allow the
surrounding tissue eventually replace the scaffold ;
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This note was uploaded on 01/12/2014 for the course MECH 810 taught by Professor Various during the Fall '13 term at Queens University.
- Fall '13