Notes on Scaffolds

The scaffold should be easily fabricated into various

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Unformatted text preview: The scaffold should be easily fabricated into various shapes and sizes [1]. 6 7. Scaffold materials must be sterilizable in order to prevent infection. The scaffolds should possess minimum residues if chemicals are used to sterilize the samples. 2.3 Bone Structure and Composition [9]: At the ultra-structural level, bone is a composite with mechanical properties that can be matched by man-made composites. As a natural tissue, bone has a complex structure where several macroscopic to microscopic levels of organization can be identified. Bone possesses an intricate structure. The basic unit of bone is the Haversian system (also known as “osteons”), which is a hollow, laminated rod of collagen and calcium phosphate. The hollow core is a nutrient channel, the Haversian canal. Many of these Haversian systems within the shaft of a long bone are bundled together in parallel and form a kind of bone called cortical or compact bone, which is optimized to handle mechanical forces. Near the ends of the bones, where the stresses become more complex, the Haversian systems play out and branch to form a meshwork of cancellous, or spongy bone. Human bone contains the mineral crystallites that are structurally calciumdeficient, carbonate-substituted hydroxyapatite that are generally referred to as bone apat...
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