Manufacturing Technical Paper

A good understanding of the composition of bone yields

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Unformatted text preview: immunogenic response. The scaffold should be made of a material with appropriate rate of degradation in order to allow the surrounding tissue eventually replace the scaffold [12]. 3. Producibility: The scaffold should be easily fabricated into various shapes and sizes [12]. 4. Osteointegration: The newly formed mineralized tissue must be able to form an intimate bonding with the implant material [13]. 2.1 Scaffold Materials Bone possesses an intricate structure. At the ultra- structural level, bone is a composite with mechanical properties that can be matched by man- made composites. As a natural tissue, bone has a complex structure where several macroscopic to microscopic levels of organization can be identified [9]. A good understanding of the composition of bone yields a good insight into the structural features of bones as well as provides the property range for approximating mechanical compatibility that is required of a bone analogue material for structural replacement with a stabilized bone- implant interface. Bone is composed of two tissues, the Cortical and the Cancellous bone. The cortical bone, forms the cortex (outer shell) of most bones. It is harder, stronger and stiffer than cancellous bones. Cancellous bone is typically found at the ends of long bones, proximal to joints and within the interior of vertebrae. It is also highly vascular and hence, less dense than cortical bone. There is a broad list of materials that have been currently used in the fabrication of TE scaffolds [14]. The selection of mate...
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