Manufacturing Technical Paper

Researchers have modified the method of deposition

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Unformatted text preview: tion (3DF) bioplotter and tested for TE scaffold fabrication [33]. Wang et al developed a variation of FDM process called precision extruding deposition (PED) system to fabricate interconnected 3D scaffolds at Drexel University [34]. Shor proposed a new system called mini- extruder mounted on high- precision positioning system deliveries the PCL or PCL- HA in a fused form through the deposition nozzle [35]. Figure 7: SEM after 20 days of curing [36] The Figure 7 above shows the SEM mineralized matrix produced by osteoblasts cultured on PCL scaffolds after 21 days of culture from an article by Lauren Shor [36]. The scaffold fabricated is providing support for the regeneration of osteoprogenitor cells. Unfortunately, this synthetic ECM is much thicker than the natural ECM described above. The size of natural ECM ranges between 50 – 500 nm. 4 NANOTECHNOLOGY AND TISSUE ENGINEERING Previously, scaffolds that have been developed have thicker fibers than those that are naturally present in the extracellular matrix (ECM) [36]. In addition, most scaffolds that are used in tissue engineering lack the function of active agent storage and release. To be able to mimic this nanoscale structure, it is essential to build scaffolds from nanofibers (n- fibers). 4.1 Electospinning Electrospinning is a process that was first conceived in the late 19th century by Lord Rayleigh [38]. It is the most cost effective of all the methods that fabricate nanofibers and less lab intensive. In its simplest form, electrospinning...
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This note was uploaded on 01/14/2014 for the course MECH 810 taught by Professor Various during the Fall '13 term at Queens University.

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