Manufacturing Presentation

Providing cellular prostheses or replacement parts

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Unformatted text preview: AR MATRIX cont’d Through the interacHon of the ECM with receptors on the surfaces of the cells, it directly takes part in promoHng cell adhesion, migraHon, growth, differenHaHon, and apoptosis [46]. TISSUE ENGINEERING cont’d InteracHons between the cells and the ECM are dynamic and play criHcal roles during development, wound healing, and environmental maintenance [46] Tissue Engineering is concerned with the technologies that develop arHficial Hssue/organ for the improvement or replacement of lost or damaged human Hssue/organ [8,19]. TISSUE ENGINEERING cont’d In terms of its goals, Tissue Engineering can be considered as follows [9,37]: 1. Providing cellular prostheses or replacement parts for the human body. 2. Providing acellular replacement parts capable of inducing regeneraHon. 3. Providing Hssue or organ- like model systems populated with cells for basic research and for many applied uses such as the study of disease states using aberrant cells. 4. Providing vehicles for delivering engineered cells to the organism. 5. Providing surfacing non- biological devices. SCAFFOLDS The latest TE technology combines cells, scaffolds, and signaling substances to both physically and biologically regenerate Hssue [8,22,24]. Typical scaffolds structures try to temporarily mimic the natural extracellular matrix of the Hssue [2]. Assuming the role of a syntheHc extracellular matrix (ECM), permits cell adhesion, proliferaHon, and differenHaHon for surgical implantaHons [8,22,23]. Therefore, the scaffolds are essenHally three- dimensional (3D) to facilitate cell amachment, growth, and neoHssue formaHon [8,25]. SCAFFOLDS cont’d Scaffold design controls the cells and ulHmately Hssue growth by balancing mechanical funcHon with drug delivery, as well as degradaHon of the scaffold adjusted to Hssue regeneraHon [1]. Some requirements exist that a successful scaffold for bone Hssue (or osseous Hssue) engineering must meet [9]: OsteoconducHvity: The porous interconnected structure perminng new cells to amach, proliferate, and migrate through the structure and also allows for the exchange of nutrient- waste as well as new blood vessels penetraHon; SCAFFOLDS cont’d OsteoinducHvity: Having the quality for possessing the necessary proteins and growth factors which can induce the progression of mesenchymal stem cells and other osteoprogenitor cells toward the osteoblast lieage; Osteogenecity: The osteobl...
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This note was uploaded on 01/14/2014 for the course MECH 810 taught by Professor Various during the Fall '13 term at Queens University.

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